Patients with severely reduced blood flow due to microcirculation damage from type 2 diabetes mellitus are at increased risk of developing complications such as painful foot ulcers. This is due to reduced blood flow and nerve damage, which prevent avoidance of undue friction and rubbing. Evaluating microcirculation dysfunction due to diabetes early in the course of the disease and treatment with modalities like D'OXYVA can help avoid complications like amputations.